Efinaconazole (Jublia) is a medication that was approved in 2014. It is a topical (applied to the skin) antifungal used for the local treatment of toenail fungus due to two most common fungal species affecting nails (Trichophyton rubrum and Trichophyton mentagrophytes). Once-daily application is required for 48 weeks. The most common side effects of Jublia are ingrown toenails and application site dermatitis and pain.
If the fungal infection has spread to the toenails, the nails must also be treated to avoid reinfection of the feet. Often, the nails are initially ignored only to find the athlete's foot keeps recurring. It is important to treat all of the visible fungus at the same time. Effective nail fungus treatment may be more intensive and require prolonged courses (three to four months) of oral antifungal medications.
As both an antiseptic and fungicidal remedy, tea tree oil is a great remedy for onychomycosis.  First clean areas on and around the infection with rubbing alcohol then apply undiluted 100% pure tea tree oil (such as this Plant Therapy Tea Tree Oil) directly to the affected nails and let it soak in.  After about ten minutes, gently scrub the nail with a soft bristle toothbrush.  When applying tea tree oil directly to skin, consider mixing the oil one-to-one with an all-natural carrier, like olive or almond oil.  Repeat daily until the new healthy nail grows out completely, then continue treatment for two to three more weeks to prevent regrowth.
The Internet is filled with anecdotal information on how to cure toenail fungus using home remedies. Vinegar is a commonly recommended home remedy. Some people apply various oils such as tea tree oil, coconut oil, essential oils, and oil of cedar leaf (such as Vicks VapoRub) to their nails as well. The effectiveness of these home remedies is highly doubtful. Application of household bleach and hydrogen peroxide is also not recommended due to lack of evidence that these treatments work. These agents can also cause unwanted skin irritation. Thickened nails that have been affected by fungus can be difficult to trim. Using topical urea cream will soften the nail and make it easier to trim. These creams do not require a prescription.
Fungal nail infections don’t usually lead to serious long-term problems when properly treated, but they may be more serious in certain individuals. This can include people with diabetes or who have a weakened immune system and have trouble fighting off an infection. Even if there is no pain associated with the infection, it is important that you promptly visit your doctor for assessment if you see any abnormal nail changes.

Conventional treatment typically involves thoroughly washing the feet daily or twice daily, followed by the application of a topical medication. Because the outer skin layers are damaged and susceptible to reinfection, topical treatment generally continues until all layers of the skin are replaced, about 2–6 weeks after symptoms disappear. Keeping feet dry and practicing good hygiene (as described in the above section on prevention) is crucial for killing the fungus and preventing reinfection.
If the diagnosis is uncertain, direct microscopy of a potassium hydroxide preparation of a skin scraping (known as a KOH test) can confirm the diagnosis of athlete's foot and help rule out other possible causes, such as candidiasis, pitted keratolysis, erythrasma, contact dermatitis, eczema, or psoriasis.[13][23][27] Dermatophytes known to cause athlete's foot will demonstrate multiple septate branching hyphae on microscopy.[13]
Nail-bed fungus is also called onychomycosis. It can affect anyone regardless of age, gender and hygiene and is spread by direct contact with skin or with infected surfaces. Common places you may be exposed to fungus are at nail salons, as well as showers at hotels, pools, nail salons, and gyms where you go barefoot. Housemates and family members with a fungal infection may also spread their condition.
Caprylic acid, one of the medium-chain fatty acids in coconut oil, has the ability to penetrate the durable cell wall of candida and other fungi.  Without its protective coating the cells of the fungus dissolve, effectively destroying the infection.  Apply a thin layer of coconut oil to infected areas and let it soak in for at least fifteen minutes.  Coconut oil is great for skin health, so there is no limit to how often you can use this treatment.  Just make sure you aren’t allergic to coconuts before applying this product to sensitive tissue.

Wei, Y.-X., Xu, X.-Y., Xu, & Song, X. (2017). A review of antifungal natural products against the pathogenic fungi causing athletes' foot disease. Current Organic Chemistry, 21, 1–13. Retrieved from https://www.researchgate.net/profile/Xun_Song/publication/319128408_A_Review_of_Antifungal_Natural_Products_Against_the_Pathogenic_Fungi_Causing_Athletes'_Foot_Disease/links/59931c65458515c0ce61efa1/A-Review-of-Antifungal-Natural-Products-Against-the-Pathogenic-Fungi-Causing-Athletes-Foot-Disease.pdf

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